Effects of Home Care on patients with hepatocellular carcinoma treated with sorafenib

JGH Open

卷:5

Jean‐François Dufour¹  Monika Moser¹  Iuliana‐Pompilia Radu¹ 

[1] Hepatology, Department of Clinical Research University of Bern Bern Switzerland;

关键词: liver cancer;    oncology;    quality of life;    sorafenib;    treatment;   

DOI  :  10.1002/jgh3.12533

来源: DOAJ

【 摘 要 】

Abstract Background and Aim Treatment with sorafenib causes diverse side effects, which limits adherence. This work assesses whether Home Care, a psychosocial nursing intervention, prolongs the duration of treatment in patients with advanced hepatocellular carcinoma (HCC) and if it influences health‐related quality of life (HRQL). Methods and Results This is a cohort study using data from patients receiving sorafenib in the prospective Bern HCC Cohort at the University Hospital. Duration of treatment, overall survival, and HRQL using the Functional Assessment of Cancer Therapy‐Hepatobiliary questionnaire were compared in the two groups. A total of 173 patients were eligible for the analysis. Among them, 141 were in the Home Care program, and 32 were not. Patients with Home Care had a significantly longer duration of treatment (265 days vs 152 days, P = 0.003) and a better functional well‐being (17.7 vs 12.5, P = 0.015). Conclusion Psychosocial interventions such as Home Care are a valid method in improving adherence to sorafenib and can therefore be recommended.

【 授权许可】

Unknown