Glycyrrhiza uralensis Fisch. and its active components mitigate Semen Strychni-induced neurotoxicity through regulating high mobility group box 1 (HMGB1) translocation

Biomedicine & Pharmacotherapy

卷:149

Yalan Xiang¹  Jing Wen¹  Bikui Zhang¹  Gongying Deng¹  Lu Wang²  Miao Yan³  Changwei Yu³  Chao Wang³  Xiaoyu Duan³  Pingfei Fang³  Min Zhang⁴ 

[1] Institute of Clinical Pharmacy, Central South University, Changsha 410011, China;

[2] Department of Pharmacy, Qingdao Municipal Hospital, Qingdao 266011, China;

[3] Department of Pharmacy, The Seond Xiangya Hospital, Central South University, Changsha 410011, China;

[4] Department of Pharmacy, The Third Hospital of Changsha, Changsha 410015, China;

关键词: Semen Strychni;    Neurotoxicity;    Liquorice;    Neuroprotection;    HMGB1;   

DOI  :  

来源: DOAJ

【 摘 要 】

Semen Strychni has long been used for the treatment of rheumatoid arthritis, facioplegia and myasthenia gravis due to its anti-inflammation and anti-nociceptive properties in China. However, the fatal neurotoxicity of Semen Strychni has limited its wider clinical application. To investigate the acute toxicity induced by Semen Strychni and the detoxification of liquorice, we evaluated inflammation, oxidative stress and the translocation of high mobility group box 1 (HMGB1) in rats. As a result, there were obvious oxidative stress and inflammation in hippocampus after the Semen Strychni extracts (STR) treatment in rats. Liquorice extracts (LE) and its three active monomers – glycyrrhizic acid (GA), liquiritigenin (LIQ), isoliquiritigenin (ISL) showed the potential for mitigating STR-induced neurotoxicity. HMGB1 levels in cytoplasm and serum and the levels of two downstream receptors RAGE and TLR4 were significantly increased after STR treatment. Through using LE and the monomers, the nucleocytoplasmic transport and release of HMGB1 were inhibited. In addition, the binding between HMGB1 and TLR4 was weakened in detoxification groups comparing with the STR group. Taken together, these findings indicated that liquorice and its active components alleviated acute neurotoxicity induced by Semen Strychni partly via HMGB1-related pathway.

【 授权许可】

Unknown