The bacterial pangenome as a new tool for analysing pathogenic bacteria

New Microbes and New Infections

卷:7

关键词: Bacteria;    bioinformatics tools;    comparative genomics;    pangenome;    pathogenic species;   

DOI  :  10.1016/j.nmni.2015.06.005

来源: DOAJ

【 摘 要 】

The bacterial pangenome was introduced in 2005 and, in recent years, has been the subject of many studies. Thanks to progress in next-generation sequencing methods, the pangenome can be divided into two parts, the core (common to the studied strains) and the accessory genome, offering a large panel of uses. In this review, we have presented the analysis methods, the pangenome composition and its application as a study of lifestyle. We have also shown that the pangenome may be used as a new tool for redefining the pathogenic species. We applied this to the Escherichia coli and Shigella species, which have been a subject of controversy regarding their taxonomic and pathogenic position.

【 授权许可】

Unknown