Does the Combined Effect of Resistance Training with EPO and Iron Sulfate Improve Iron Metabolism in Older Individuals with End-Stage Renal Disease?

Nutrients

卷:13

Beatriz Carneiro Habbema Maia¹  Lucas Santos de Gusmão Alves¹  Rafaela Araújo Machado¹  Fernanda Silveira Tavares¹  Artur Temizio Oppelt Raab¹  Isabela Akaishi Padula¹  Luiz Sinésio da Silva Neto²  Rosângela Vieira Andrade³  Fernando Sousa Honorato⁴  Andrea Lucena Reis⁴  Jonato Prestes⁴  Carlos Ernesto Santos Ferreira⁴  Victor Lopes Silva⁴  Lysleine Alves Deus⁴  Rodrigo Vanerson Passos Neves⁴  Thiago dos Santos Rosa⁴  Hugo de Luca Corrêa⁴  Sting Ray Gouveia Moura⁴  Víctor Manuel Alfaro-Magallanes⁵ 

[1] Department of Medicine, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil;

[2] Faculty of Medicine, Federal University of Tocantins, Para 77402-970, Brazil;

[3] Graduate Program of Genomic Sciences and Biotechnology, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil;

[4] Graduate Program of Physical Education, Catholic University of Brasilia, Federal District, Brasilia 71966-700, Brazil;

[5] LFE Research Group, Department of Health and Human Performance, Faculty of Physical Activity and Sport Sciences (INEF), Universidad Politécnica de Madrid (UPM), 28040 Madrid, Spain;

关键词: iron metabolism;    chronic kidney disease;    hepcidin;    erythropoietin;    exercise training;    anemia;   

DOI  :  10.3390/nu13093250

来源: DOAJ

【 摘 要 】

We sought to investigate the effects of resistance training (RT) combined with erythropoietin (EPO) and iron sulfate on the hemoglobin, hepcidin, ferritin, iron status, and inflammatory profile in older individuals with end-stage renal disease (ESRD). ESRD patients (n: 157; age: 66.8 ± 3.6; body mass: 73 ± 15; body mass index: 27 ± 3), were assigned to control (CTL; n: 76) and exercise groups (RT; n: 81). The CTL group was divided according to the iron treatment received: without iron treatment (CTL—none; n = 19), treated only with iron sulfate or EPO (CTL—EPO or IRON; n = 19), and treated with both iron sulfate and EPO (CTL—EPO + IRON; n = 76). The RT group followed the same pattern: (RT—none; n = 20), (RT—EPO or IRON; n = 18), and (RT—EPO + IRON; n = 86). RT consisted of 24 weeks/3 days per week at moderate intensity of full-body resistance exercises prior to the hemodialysis section. The RT group, regardless of the iron treatment, improved iron metabolism in older individuals with ESRD. These results provide some clues on the effects of RT and its combination with EPO and iron sulfate in this population, highlighting RT as an important coadjutant in ESRD-iron deficiency.

【 授权许可】

Unknown