An Occult HPV-Driven Oropharyngeal Squamous Cell Carcinoma Discovered Through a Saliva Test

Frontiers in Oncology

卷:10

Lizbeth Kenny¹  Brett G. M. Hughes³  Sarju Vasani⁴  Kai Dun Tang⁵  Chamindie Punyadeera⁵  Touraj Taheri⁷  Laurence J. Walsh⁸ 

[1] Central Integrated Regional Cancer Service, Queensland Health, Brisbane, QLD, Australia;

[2] Department of Anatomical Pathology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia;

[3] Department of Cancer Care Services, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia;

[4] Department of Otolaryngology, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia;

[5] Institute of Health and Biomedical Innovation, Translational Research Institute, Brisbane, QLD, Australia;

[6] Saliva and Liquid Biopsy Translational Research Team, The School of Biomedical Sciences, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia;

[7] School of Medicine, The University of Queensland, Brisbane, QLD, Australia;

[8] The University of Queensland School of Dentistry, Brisbane, QLD, Australia;

关键词: human papillomavirus;    oropharyngeal cancer;    saliva;    screening tools;    biomarker;   

DOI  :  10.3389/fonc.2020.00408

来源: DOAJ

【 摘 要 】

Oropharyngeal cancer (OPC) caused by human papillomavirus (HPV) is a rising global concern. Early lesions are small and are often located in difficult to access areas (such as the crypts of the tonsils or base of tongue). Unlike cervical cancer, there is no standard or routine screening program for HPV-driven OPC. HPV DNA from OPC tumors may shed directly into saliva, and this can be used as a biomarker for early diagnosis. In this study, we report the first-ever clinically occult OPC in an asymptomatic patient discovered through a saliva test. This case relied upon serial measurements of HPV-16 DNA in saliva, which fell to undetectable levels following low morbidity, curative treatment.

【 授权许可】

Unknown