Implications of intravital imaging of murine germinal centres on the control of B cell selection and division

Frontiers in Immunology

卷:7

Michael Meyer-Hermann¹  Sebastian C. Binder¹ 

[1] Helmholtz Centre for Infection Research and Braunschweig Integrated Centre of Systems Biology;

关键词: Chemotaxis;    Germinal Center;    Affinity maturation;    T follicular helper cells;    antibody optimization;    B cell motility;   

DOI  :  10.3389/fimmu.2016.00593

来源: DOAJ

【 摘 要 】

Intravital imaging of antibody optimization in germinal centre (GC) reactions hasset a new dimension in the understanding of the humoral immune response duringthe last decade. The inclusion of spatio-temporal cellular dynamics inthe research on GCs required analysis with agent-based mathematical models.Here, we integrate the available intravital imaging data from various researchgroups and incorporate these into a quantitative mathematical model ofGC reactions and antibody affinity maturation. Interestingly, the integrationof data concerning the spatial organisation of GCs and B cell motility allows to drawconclusions on the strength of the selection pressure and the controlof B cell division by T follicular helper cells.

【 授权许可】

Unknown