Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering

Molecules

卷:27

Long-Ge Hu¹  Chun-Yang Zhang¹  Shi-Bin Wang¹  Xiong-Ya Li¹  Ranjith Kumar Kankala¹  Xiao-Chang Lu¹  Chao-Ping Fu¹  Ai-Zheng Chen¹ 

[1] Institute of Biomaterials and Tissue Engineering, Huaqiao University, Xiamen 361021, China;

关键词: 3D bioprinting;    bioink;    decellularized extracellular matrix;    tissue engineering;   

DOI  :  10.3390/molecules27113442

来源: DOAJ

【 摘 要 】

Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D printing to create cell-laden structures. Recently, decellularized extracellular matrix (dECM)-based bioinks derived from natural tissues have garnered enormous attention from researchers due to their unique and complex biochemical properties. This review initially presents the details of the natural ECM and its role in cell growth and metabolism. Further, we briefly emphasize the commonly used decellularization treatment procedures and subsequent evaluations for the quality control of the dECM. In addition, we summarize some of the common bioink preparation strategies, the 3D bioprinting approaches, and the applicability of 3D-printed dECM bioinks to tissue engineering. Finally, we present some of the challenges in this field and the prospects for future development.

【 授权许可】

Unknown