Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis

Pharmaceuticals

卷:12

LuanKelves Miranda de Souza¹  ReycaRodrigues e Silva¹  JandVenes Rolim Medeiros¹  DurcileneAlves da Silva¹  GerlyAnne de Castro Brito²  JoãoErivan Façanha Barreto²  AnaPaula Fragoso de Freitas²  RenataFerreira de Carvalho Leitão²  PauloVitor de Souza Pimentel²  DainesySantos Martins²  ArielGustavo Scafuri²  GilbertoSantos Cerqueira²  DeizianeViana da Silva Costa²  JoãoAntônio Leal de Miranda²  CamilaNayane de Carvalho Lima³  JeffersonAlmeida Rocha⁴ 

[1] Biotechnology and Biodiversity Center Research, BIOTEC, Federal University of Piauí, Parnaíba, Piauí 64202-020, Brazil;

[2] Department of Morphology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, Fortaleza 60416-030, Brazil;

[3] Nucleus of Research and Development of Medications (NPDM), Federal University of Ceará, Coronel Nunes de Melo Street, 100, Fortaleza 60430-275, Brazil;

[4] Research Group in Natural Sciences and Biotechnology, Federal University of Maranhão, s/n Avenue Aurila Maria Santos Barros de Sousa, Frei Alberto Beretta, Grajaú-MA 65940-000, Brazil;

关键词: intestinal mucositis;    heteropolysaccharide;    5-fluorouracil;    inflammation;   

DOI  :  10.3390/ph12020051

来源: DOAJ

【 摘 要 】

Intestinal mucositis is a common complication associated with 5-fluorouracil (5-FU), a chemotherapeutic agent used for cancer treatment. Cashew gum (CG) has been reported as a potent anti-inflammatory agent. In the present study, we aimed to evaluate the effect of CG extracted from the exudate of Anacardium occidentale L. on experimental intestinal mucositis induced by 5-FU. Swiss mice were randomly divided into seven groups: Saline, 5-FU, CG 30, CG 60, CG 90, Celecoxib (CLX), and CLX + CG 90 groups. The weight of mice was measured daily. After treatment, the animals were euthanized and segments of the small intestine were collected to evaluate histopathological alterations (morphometric analysis), levels of malondialdehyde (MDA), myeloperoxidase (MPO), and glutathione (GSH), and immunohistochemical analysis of interleukin 1 beta (IL-1β) and cyclooxygenase-2 (COX-2). 5-FU induced intense weight loss and reduction in villus height compared to the saline group. CG 90 prevented 5-FU-induced histopathological changes and decreased oxidative stress through decrease of MDA levels and increase of GSH concentration. CG attenuated inflammatory process by decreasing MPO activity, intestinal mastocytosis, and COX-2 expression. Our findings suggest that CG at a concentration of 90 mg/kg reverses the effects of 5-FU-induced intestinal mucositis.

【 授权许可】

Unknown