Microencapsulation of Erlotinib and Nanomagnetite Supported in Chitosan as Potential Oncologic Carrier

Polymers

卷:13

Galo Cárdenas-Triviño¹  Luis Vergara-González²  Sebastián Monsalve-Rozas² 

[1]DIMAD, School of Chemical Engineering, Faculty of Engineering, University of Bío-Bío, 1201 I. Collao Ave, Concepción 4081112, Chile

[2]|Department of Biological and Chemistry Sciences, Faculty of Medicine and Science, San Sebastian University, Las Tres Pascualas Campus, Concepción 4030035, Chile

关键词: chitosan;    nanocomposites;    drug delivery;    biomedical applications;    microencapsulation;   

DOI  :  10.3390/polym13081244

来源: DOAJ

【 摘 要 】

Microcapsules (MC) based on chitosan (CH) and including nano-magnetite and erlotinib were synthesized. The microparticles were characterized by SEM, FT-IR and TGA. The percentage of encapsulation was determined, as well as its microbiological activity. Finally, the effectiveness of the formulation was evaluated in terms of cell viability and/or toxicity when compared with the reference drug. The formulation used to prepare the microcapsules showed some bacteriostatic properties. The characterization of microcapsules exhibited amorphous spherical shape and average size of 1.29, 1.58 and 1.62 mm for chitosan, chitosan + nanomagnetite and chitosan + nanomagnetite + erlotinib, respectively. The infrared spectra showed characteristic bands of the erlotinib and magnetite, confirming its internalization. The thermogravimetric analyzes indicated that the materials do not undergo changes at optimum working temperatures. The HPLC analysis showed a 52% of encapsulation. Finally, the formulation probed had lower effectiveness and less cytotoxicity, than the drug without encapsulating “in vitro” studies. For that reason several assays are in progress.

【 授权许可】

Unknown