The Emerging Field of Epitranscriptomics in Neurodevelopmental and Neuronal Disorders

Frontiers in Bioengineering and Biotechnology

卷:6

Margarita T. Angelova¹  Dilyana G. Dimitrova¹  Clément Carré¹  Lina Worpenberg²  Tina Lence²  Jean-Yves Roignant²  Nadja Dinges² 

[1] Drosophila Genetics and Epigenetics, Sorbonne Université, Centre National de la Recherche Scientifique, Biologie du Développement—Institut de Biologie Paris Seine, Paris, France;

[2] Laboratory of RNA Epigenetics, Institute of Molecular Biology, Mainz, Germany;

关键词: RNA modification;    m5C;    Nm;    pseudouridine;    m6A;    neurons;   

DOI  :  10.3389/fbioe.2018.00046

来源: DOAJ

【 摘 要 】

Analogous to DNA methylation and histone modifications, RNA modifications represent a novel layer of regulation of gene expression. The dynamic nature and increasing number of RNA modifications offer new possibilities to rapidly alter gene expression upon specific environmental changes. Recent lines of evidence indicate that modified RNA molecules and associated complexes regulating and “reading” RNA modifications play key roles in the nervous system of several organisms, controlling both, its development and function. Mutations in several human genes that modify transfer RNA (tRNA) have been linked to neurological disorders, in particular to intellectual disability. Loss of RNA modifications alters the stability of tRNA, resulting in reduced translation efficiency and generation of tRNA fragments, which can interfere with neuronal functions. Modifications present on messenger RNAs (mRNAs) also play important roles during brain development. They contribute to neuronal growth and regeneration as well as to the local regulation of synaptic functions. Hence, potential combinatorial effects of RNA modifications on different classes of RNA may represent a novel code to dynamically fine tune gene expression during brain function. Here we discuss the recent findings demonstrating the impact of modified RNAs on neuronal processes and disorders.

【 授权许可】

Unknown