Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review

Precision and Future Medicine

卷:3

Jong-Sun Kang¹  Hyebeen Kim¹  Hyun-Ju Jeong² 

[1] Department of Molecular Cell Biology, Single Cell Network Research Center, Sungkyunkwan University School of Medicine, Suwon, Korea;

[2] ;

关键词: muscle, skeletal;    regeneration;    metabolism;    protein arginine methyltransferase;   

DOI  :  10.23838/pfm.2019.00107

来源: DOAJ

【 摘 要 】

Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated in diverse processes, including muscle regeneration and metabolic homeostasis. Reciprocally, loss of skeletal muscle mass and function related to aging or other pathological conditions could be related to the secondary chronic diseases, for example, metabolic syndromes, chronic inflammation, or cardiovascular diseases. Thus, understanding the pathways that regulate muscle homeostasis is critical to develop therapeutic strategies for preventing muscle loss and related secondary chronic diseases. Recent in vivo research using gene-targeting mouse models have advanced our knowledge about the role of several PRMTs in muscle regeneration and metabolic controls. In this review, we will focus on the recent discoveries on the in vivo function of PRMTs in muscle homeostasis.

【 授权许可】

Unknown