Serum antibody response in COVID-19-recovered patients who retested positive

Canada Communicable Disease Report

卷:47

Imran Gabrani-Juma¹  Megan Striha¹  Emily Thompson¹  Nicole Atchessi¹  Rojiemiahd Edjoc¹  Amanda Lien¹  Christine Abalos¹  Thomas Dawson¹  Lisa Waddell² 

[1] Health Security and Operations Branch, Public Health Agency of Canada, Ottawa, ON;

[2] Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB;

关键词: covid-19;    sars-cov-2;    rt-pcr;    false-negative;    reinfection;    retesting;   

DOI  :  10.14745/ccdr.v47i04a03

来源: DOAJ

【 摘 要 】

Background: Research studies comparing antibody response from coronavirus disease 2019 (COVID-19) cases that retested positive (RP) using reverse transcription polymerase chain reaction (RT-PCR) and those who did not retest positive (NRP) were used to investigate a possible relationship between antibody response and retesting status.Methods: Seven data bases were searched. Research criteria included cohort and case-control studies, carried out worldwide and published before September 9, 2020, that compared the serum antibody levels of hospitalized COVID-19 cases that RP after discharge to those that did NRP.Results: There is some evidence that immunoglobulin G (IgG) and immunoglobulin M (IgM) antibody levels in RP cases were lower compared with NRP cases. The hypothesis of incomplete clearance aligns with these findings. The possibility of false negative reverse transcription polymerase chain reaction (RT-PCR test results during viral clearance is also plausible, as concentration of the viral ribonucleic acid (RNA) in nasopharyngeal and fecal swabs fluctuate below the limits of RT-PCR detection during virus clearance. The probability of reinfection was less likely to be the cause of retesting positive because of the low risk of exposure where cases observed a 14 day-quarantine after discharge.

【 授权许可】

Unknown