Fatty Acid Metabolism in Ovarian Cancer: Therapeutic Implications

International Journal of Molecular Sciences

卷:23

Hyunho Yoon¹  Sanghoon Lee² 

[1] Department of Medical and Biological Sciences, The Catholic University of Korea, Bucheon 14662, Korea;

[2] Department of Obstetrics and Gynecology, Korea University College of Medicine, Seoul 02841, Korea;

关键词: lipid metabolism;    immune response;    ovarian cancer;    tumor microenvironment;   

DOI  :  10.3390/ijms23042170

来源: DOAJ

【 摘 要 】

Ovarian cancer is the most malignant gynecological tumor. Previous studies have reported that metabolic alterations resulting from deregulated lipid metabolism promote ovarian cancer aggressiveness. Lipid metabolism involves the oxidation of fatty acids, which leads to energy generation or new lipid metabolite synthesis. The upregulation of fatty acid synthesis and related signaling promote tumor cell proliferation and migration, and, consequently, lead to poor prognosis. Fatty acid-mediated lipid metabolism in the tumor microenvironment (TME) modulates tumor cell immunity by regulating immune cells, including T cells, B cells, macrophages, and natural killer cells, which play essential roles in ovarian cancer cell survival. Here, the types and sources of fatty acids and their interactions with the TME of ovarian cancer have been reviewed. Additionally, this review focuses on the role of fatty acid metabolism in tumor immunity and suggests that fatty acid and related lipid metabolic pathways are potential therapeutic targets for ovarian cancer.

【 授权许可】

Unknown