Maternal green tea extract intake during lactation attenuates hepatic lipid accumulation in adult male rats exposed to a continuous high-fat diet from the foetal period

Food & Nutrition Research

卷:64

Shin Sato¹  Masaaki Kurasaki²  Takeshi Saito³  Rahel Mesfin Ketema⁴  Tomomi Tomihara⁴  Shojiro Yamasaki⁴  Ning Dai⁴  Yukako Ueno⁴  Goh Kimura⁴  Yuki Ohno⁴  Kazunari Koizumi⁴  Toshiyuki Hosokawa⁵ 

[1] Department of Nutrition, Aomori University of Health and Welfare, Aomori, Japan;

[2] Faculty of Environmental Earth Science, Hokkaido University, Sapporo, Japan;

[3] Faculty of Health Sciences, Hokkaido University, Sapporo, Japan;

[4] Graduate School of Health Sciences, Hokkaido University, Sapporo, Japan;

[5] Institute for the Advancement of Higher Education, Hokkaido University, Sapporo, Japan;

关键词: maternal supplements;    high-fat diet;    green tea extract;    adult offspring;    hepatic fat accumulation;   

DOI  :  10.29219/fnr.v64.5231

来源: DOAJ

【 摘 要 】

Background: Maternal lipid intake in the early postnatal period has a long-term effect on the possibility of fatty liver formation in children; besides, the importance of lipid consumption during lactation for children’s health has been suggested. Green tea extract (GTE) contains abundant catechins, and it has been reported to improve lipid metabolism and prevent fatty liver. Objective: The aim of this study was to examine the effects of maternal GTE intake during lactation on hepatic lipid accumulation in adult male rats exposed to a continuous high-fat (HF) diet from the foetal period. Methods: Pregnant Wistar rats received diets containing 13% (control-fat, CON) or 45% (high-fat, HF) fat. CON-fed mothers received the same diet during lactation, whereas HF-fed mothers received either HF diet alone or HF diet supplemented with 0.24% GTE. At weaning, male offspring were divided into three groups, i.e. CON/CON/CON, HF/HF/HF (HF-offspring) or HF/HF+GTE/HF (GTE-offspring), and were fed until 51 weeks. Results: A significant hepatic triglyceride (Tg) accumulation was observed in the HF-offspring when compared with the other offspring. This is presumed to be caused by the promotion of Tg synthesis derived from exogenous fatty acid due to a significant increase in diacylglycerol O-acyltransferase 1 and a decrease in Tg expenditure caused by decreasing microsomal triglyceride transfer protein (MTTP) and long-chain acyl-CoA dehydrogenase. On the other hand, attenuated hepatic Tg accumulation was observed in the GTE-offspring. The levels of the hepatic lipid metabolism-related enzymes were improved to the same level as the CON-offspring, and particularly, MTTP was significantly increased as compared with the HF-offspring. Conclusion: This study indicates the potential protective effects of maternal GTE intake during lactation on HF diet-induced hepatic lipid accumulation in adult male rat offspring and the possible underlying mechanisms.

【 授权许可】

Unknown