Biodegradable magnesium barrier membrane used for guided bone regeneration in dental surgery

Bioactive Materials

卷:14

Drazen Tadic¹  Željka Perić Kačarević¹  Daniel Rothamel²  Gerrit Sauer³  Fabien Bornert³  Dávid Botond Hangyási⁴  Peter Windisch⁴  Balint Molnar⁵  Emely Bortel⁶  Bernhard Hesse⁶  Frank Witte⁶  Akiva Elad⁷  Patrick Rider⁷ 

[1] Botiss Biomaterials AG, Ullsteinstrasse 108, 12109, Berlin, Germany;

[2] Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, Osijek, 31000, Croatia;

[3] CMF Surgery, Johannes BLA Hospital, Mönchengladbach, Germany;

[4] Dental Clinic, University of Strasbourg, France;

[5] Department of Periodontology, Semmelweis University, Budapest, Hungary;

[6] Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charité – Universitätsmedizin Berlin, Aßmannshauser Straße 4–6, 14197, Berlin, Germany;

关键词: Magnesium;    Biodegradable;    Implant;    GBR;    Bone healing;    Soft tissue healing;   

DOI  :  

来源: DOAJ

【 摘 要 】

Barrier membranes are commonly used as part of the dental surgical technique guided bone regeneration (GBR) and are often made of resorbable collagen or non-resorbable materials such as PTFE. While collagen membranes do not provide sufficient mechanical protection of the covered bone defect, titanium reinforced membranes and non-resorbable membranes need to be removed in a second surgery. Thus, biodegradable GBR membranes made of pure magnesium might be an alternative. In this study a biodegradable pure magnesium (99.95%) membrane has been proven to have all of the necessary requirements for an optimal regenerative outcome from both a mechanical and biological perspective. After implantation, the magnesium membrane separates the regenerating bone from the overlying, faster proliferating soft tissue. During the initial healing period, the membrane maintained a barrier function and space provision, whilst retaining the positioning of the bone graft material within the defect space. As the magnesium metal corroded, it formed a salty corrosion layer and local gas cavities, both of which extended the functional lifespan of the membrane barrier capabilities. During the resorption of the magnesium metal and magnesium salts, it was observed that the membrane became surrounded and then replaced by new bone. After the membrane had completely resorbed, only healthy tissue remained. The in vivo performance study demonstrated that the magnesium membrane has a comparable healing response and tissue regeneration to that of a resorbable collagen membrane. Overall, the magnesium membrane demonstrated all of the ideal qualities for a barrier membrane used in GBR treatment.

【 授权许可】

Unknown