Acute generalized exanthematous pustulosis induced by hydroxychloroquine: a case with atypical clinical presentation

Anais Brasileiros de Dermatologia

卷:92

关键词: Acute generalized exanthematous pustulosis;    Hydroxychloroquine;    Erythema multiforme;   

DOI  :  10.1590/abd1806-4841.20175561

来源: DOAJ

【 摘 要 】

Abstract Acute generalized exanthematous pustulosis is a rare drug-induced eruption that is characterized by acute, nonfollicular sterile pustules on an erythematous and edematous base. The most frequently implicated drugs are beta-lactam antibiotics. Hydroxychloroquine has been widely used to treat dermatologic and rheumatologic diseases and has been reported as a rare cause of acute generalized exanthematous pustulosis. A 42-year-old female presented with pustular lesions on the skin surface with erythema, facial edema, and occasional atypical target-like lesions after 21 days of treatment with 200mg/day hydroxychloroquine for rheumatoid arthritis, diagnosed one month previously. We report a case with acute generalized exanthematous pustulosis induced by hydroxychloroquine and treated with dapsone and systemic corticosteroid.

【 授权许可】

Unknown