COVID-19 reinfection: the role of natural immunity, vaccines, and variants

Journal of Community Hospital Internal Medicine Perspectives

卷:11

Bao Y. Sciscent¹  Caroline D. Eisele¹  Steven D. King¹  Lisa Ho¹  Rohit Jain²  Reshma R. Golamari² 

[1] College of Medicine;

[2] Penn State Health Milton S. Hershey Medical Center;

关键词: covid-19;    reinfection;    covid-19 vaccination;    covid-19 immunity;    sars-cov-2;   

DOI  :  10.1080/20009666.2021.1974665

来源: DOAJ

【 摘 要 】

The COVID-19 pandemic has altered innumerable lives. Although recent mass vaccinations offer a glimmer of hope, the rising death toll and new variants continue to dominate the current scenario. As we begin to understand more about SARS-CoV-2 infections, the territory of reinfections with COVID-19 remains unexplored. In this review, we will discuss several aspects of reinfection: (a) How is COVID-19 reinfection characterized? (b) Does prior literature differentiate between reinfection and reactivation? (c) What SARS-CoV-2 strains do the vaccines target and can they protect against new strains? Larger and longer timeline studies are needed to understand reinfection risks. With the ongoing distribution of the SARS-CoV-2 vaccines to provide protection, the understanding of the possibility for SARS-CoV-2 reinfection remains critical. Abbreviations CDC: Centers for Disease ControlSARS-CoV-2: Severe acute respiratory syndrome coronavirus 2COVID-19: Coronavirus disease 2019RT-PCR: Reverse Transcription Polymerase Chain ReactionPASC: Post-Acute Sequelae of SARS-CoV-2 infection

【 授权许可】

Unknown