Lipid-Based Nanocarrier System for the Effective Delivery of Nutraceuticals

Molecules

卷:26

Parthasarathi Subramanian¹ 

[1] Riddet Institute, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand;

关键词: bioavailability;    liposomes;    niosomes;    physicochemical stability;    solid lipid nanoparticles;    polyphenols;   

DOI  :  10.3390/molecules26185510

来源: DOAJ

【 摘 要 】

Nutraceuticals possess several health benefits and functions; however, most nutraceuticals are prone to degradation in the gastrointestinal environment and have poor bioavailability. Application of a novel carrier system is of increasing importance to overcome obstacles and provide efficient applicability. Lipid-based nanocarriers provide a large surface-to-mass ratio, enhanced intestinal absorption by solubilization in the intestinal milieu, intestinal lymphatic transport, and altering enterocyte-based transport. A critical overview of the current limitation, preparation, and application of lipid-based nanocarriers (liposomes and niosomes) and lipid nanoparticles (SLNs and NLCs) is discussed. Physical and gastrointestinal stability and bioavailability of nanoencapsulated nutraceuticals are considered as well.

【 授权许可】

Unknown