Hair-Growth-Promoting Effects of Fermented Red Ginseng Marc and Traditional Polyherb Formula in C57BL/6 Mice

Applied Sciences

卷:11

Chang-Hyun Song¹  Sae-Kwang Ku¹  Gyu-Ryeul Park¹  DaeHwa Jung²  PhilHyun Song³  Yoon-Hae Kim⁴ 

[1] Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan 38610, Korea;

[2] Department of Pharmaceutical Engineering, Daegu Haany University, Gyeongsan 38610, Korea;

[3] Department of Urology, College of Medicine, Yeungnam University, Daegu 42415, Korea;

[4] Pung-gi Ginseng Production Farming Cooperation, Yeongju 689822, Korea;

关键词: hair growth;    growth cycle;    red ginseng marc;    polyherb;    hair length;    hair thickness;   

DOI  :  10.3390/app11031195

来源: DOAJ

【 摘 要 】

An abnormal hair-growth cycle induces hair loss, which affects psychological distress and impairs life quality. Red ginseng marc (RGM) is usually discarded as a byproduct after extracting red ginseng, but several studies have shown that the RGM still has bioactive components including ginsenosides. Therefore, the hair-growth effects of fermented RGM (fRGM) and traditional polyherb formula (PH) were examined in C57BL/6 mice. The dorsal hairs of mice were depilated, and they were topically treated with fRGM or PH at 400, 200 and 100 mg/kg or the combination of both middle doses (combi) once a day for two weeks. The hair-covering regions were significantly increased with higher doses of fRGM and PH and in combi groups, compared with the control treated with distilled water. Hair length, thickness and weight also increased in the treatment groups. In particular, the fRGM and PH increased the anagen-phased hair follicles, the follicular diameters and the dermal thickness. Immunostains for Ki-67 showed the anagen-phased cell division in the treatment groups. The beneficial effects were greater in the high doses of fRGM and PH and the combi groups. These suggest hair-growth-promoting effects of fRGM, PH and the combination by enhancing the hair-growth cycle.

【 授权许可】

Unknown