c-Myc Oncoprotein: A Dual Pathogenic Role in Neoplasia and Cardiovascular Diseases?

Neoplasia: An International Journal for Oncology Research

卷:4

Lilach O. Lermant¹  Claudio Napoli²  Filomena de Nigris²  Vincenzo Sica³ 

[1] Department of Internal Medicine, Division of Hypertension, Mayo Clinic and Foundation, Rochester, MN, USA;

[2] Department of Medicine, University of California at San Diego, San Diego, CA, USA;

[3] Division of Clinical Pathology, Second University of Naples, Italy;

关键词: c-Myc;    cancer;    heart;    artery;    atherosclerosis;    References;   

DOI  :  10.1038/sj.neo.7900232

来源: DOAJ

【 摘 要 】

A growing body of evidence indicates that c-Myc can play a pivotal role both in neoplasia and cardiovascular diseases. Indeed, alterations of the basal machinery of the cell and perturbations of c-Myc-dependent signaling network are involved in the pathogenesis of certain cardiovascular disorders. Down-regulation of c-Myc induced by intervention with antioxidants or by antisense technology may protect the integrity of the arterial wall as well as neoplastic tissues. Further intervention studies are necessary to investigate the effects of tissue-specific block of c-Myc overexpression in the development of cardiovascular diseases.

【 授权许可】

Unknown