Chemical screen identifies a geroprotective role of quercetin in premature aging

Protein & Cell

卷:10

Piu Chan¹  Guang-Hui Liu¹  Lingling Geng¹  Weiqi Zhang¹  Yao Su¹  Wei Li¹  Peichang Wang¹  Zhenyu Ju²  Ruotong Ren³  Wei Wang³  Moshi Song⁴  Zeming Wu⁵  Zunpeng Liu⁵  Jing Qu⁵  Liang Sun⁶ 

[1] Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University;

[2] Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University;

[3] National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences;

[4] State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences;

[5] State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences;

[6] The MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology;

关键词: Quercetin;    Stem cell;    Aging;    Werner syndrome;    Hutchinson-Gilford progeria syndrome;   

DOI  :  10.1007/s13238-018-0567-y

来源: DOAJ

【 摘 要 】

Abstract Aging increases the risk of various diseases. The main goal of aging research is to find therapies that attenuate aging and alleviate aging-related diseases. In this study, we screened a natural product library for geroprotective compounds using Werner syndrome (WS) human mesenchymal stem cells (hMSCs), a premature aging model that we recently established. Ten candidate compounds were identified and quercetin was investigated in detail due to its leading effects. Mechanistic studies revealed that quercetin alleviated senescence via the enhancement of cell proliferation and restoration of heterochromatin architecture in WS hMSCs. RNA-sequencing analysis revealed the transcriptional commonalities and differences in the geroprotective effects by quercetin and Vitamin C. Besides WS hMSCs, quercetin also attenuated cellular senescence in Hutchinson-Gilford progeria syndrome (HGPS) and physiological-aging hMSCs. Taken together, our study identifies quercetin as a geroprotective agent against accelerated and natural aging in hMSCs, providing a potential therapeutic intervention for treating age-associated disorders.

【 授权许可】

Unknown