A comparison of sufentanil and fentanyl for patient-controlled epidural analgesia in arthroplasty

Korean Journal of Anesthesiology

卷:60

Se Jin Lee¹  Sung Hwan Cho¹  Hye Rim Jeon¹  Won Seok Chae¹  Sang Hyun Kim¹  Jeong Seok Lee¹  Yong Ik Kim¹  Joon Ho Lee¹  Hee Cheol Jin¹ 

[1] Department of Anesthesiology and Pain Medicine, Soonchunhyang University Hospital, Bucheon, Korea.;

关键词: epidural analgesia;    fentanyl;    ropivacaine;    sufentanil;   

DOI  :  10.4097/kjae.2011.60.1.41

来源: DOAJ

【 摘 要 】

BackgroundThe use of lipid soluble opioids such as fentanyl, alfentanil and sufentanil are recently on the increase for patient-controlled epidural analgesia (PCEA). In this study, the effects and adequate dose of sufentanil in arthroplasty were investigated.MethodsEighty patients scheduled for arthroplasty were enrolled for the study. Seventy-one patients (ASA physical status I-III) were randomly allocated into four groups. All groups received 0.1% ropivacaine through PCEA and each group received either fentanyl (group F: fentanyl 4 µg/ml) or sufentanil (group S1: sufentanil 0.5 µg/ml, group S2: sufentanil 0.75 µg/ml, and group S3: sufentanil 1.0 µg/ml). Postoperative pain scores were evaluated using VAS (visual analog scale, 0-10) and side effects such as hypotension, nausea/vomiting, pruritus and the degree of satisfaction were evaluated at 1, 6, 12, 24, 48 hours after surgery.ResultsPostoperative pain score (VAS) decreased gradually and the highest VAS score was recorded at 1 hour postoperative for all four groups. There were no differences in the degree of satisfaction and postoperative pain score between all groups. The incidence of pruritus was significantly lower in group S1 than in groups S2 and S3.ConclusionsThe incidence of side effects were significantly lower in group S1 (0.1% ropivacaine plus sufentanil 0.5 µg/ml). Therefore, 0.5 µg/ml of sufentanil through PCEA is the recommended dose for postoperative pain control in arthroplasty.

【 授权许可】

Unknown