Research progress of the role of Rho/ROCK signaling pathway in the occurrence and development of ophthalmic diseases

Guoji Yanke Zazhi

卷:21

Hong-Sheng Bi¹  Da-Dong Guo¹  Yi-Xian Hao²  Hui-Xia Wei² 

[1] Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases;

[2] Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, China;

关键词: rho/rock signaling pathway;    eye disease;    action mechanism;    regulation;   

DOI  :  10.3980/j.issn.1672-5123.2021.4.14

来源: DOAJ

【 摘 要 】

The occurrence and development of ophthalmic diseases are closely related to the abnormality of cellular regulation and ocular tissue function, in which the relevant signaling pathways play an important role in the regulation of physiological functions. The Rho/ROCK signaling pathway is involved in a variety of cellular events, including cytoskeletal reorganization, cell adhesion, cell proliferation and angiogenesis, and also plays a significant role in cell cycle progression, cell differentiation and apoptosis. Studies have shown that the Rho/ROCK signaling pathway is widely distributed in ocular tissues, and its aberrant activation can affect the normal physiological function of ocular tissues, demonstrating it is closely related to the occurrence and development of ophthalmic diseases. This paper briefly reviews the role of Rho/ROCK signaling pathway in the occurrence and development of ophthalmic diseases, providing new insights into the clinical treatment of ophthalmic diseases.

【 授权许可】

Unknown