Filterability of Erythrocytes in Patients with COVID-19

Biomolecules

卷:12

Denis N. Protsenko¹  Elizaveta A. Bovt²  Alexander G. Rumyantsev²  Fazoil I. Ataullakhanov²  Elena I. Sinauridze²  Dmitry S. Prudinnik²  Soslan S. Shakhidzhanov² 

[1] City Clinical Hospital No. 40 Moscow Health Department, Kasatkin Str., 7, 129301 Moscow, Russia;

[2] Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology, Ministry of Healthcare of Russian Federation, Samory Mashela Str., 1, GSP-7, 117198 Moscow, Russia;

关键词: COVID-19;    erythrocyte;    filterability;    SpO₂/FiO₂ ratio;    inflammation;    dynamics of filterability alteration;   

DOI  :  10.3390/biom12060782

来源: DOAJ

【 摘 要 】

For the first time, the influence of COVID-19 on blood microrheology was studied. For this, the method of filtering erythrocytes through filters with pores of 3.5 μm was used. Filterability was shown to significantly decrease with the increasing severity of the patient’s condition, as well as with a decrease in the ratio of hemoglobin oxygen saturation to the oxygen fraction in the inhaled air (SpO₂/FiO₂). The filterability of ≤ 0.65, or its fast decrease during treatment, were indicators of a poor prognosis. Filterability increased significantly with an increase in erythrocyte count, hematocrit and blood concentrations of hemoglobin, albumin, and total protein. The effect of these parameters on the erythrocyte filterability is directly opposite to their effect on blood macrorheology, where they all increase blood viscosity, worsening the erythrocyte deformability. The erythrocyte filterability decreased with increasing oxygen supply rate, especially in patients on mechanical ventilation, apparently not due to the oxygen supplied, but to the deterioration of the patients’ condition. Filterability significantly correlates with the C-reactive protein, which indicates that inflammation affects the blood microrheology in the capillaries. Thus, the filterability of erythrocytes is a good tool for studying the severity of the patient’s condition and his prognosis in COVID-19.

【 授权许可】

Unknown