Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

Microorganisms

卷:8

CarolSze Ki Lin¹  Patrick Fickers²  Hairong Cheng³ 

[1] Department of Energy and Environment, School of Energy and Environment, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong;

[2] Department of Microbial Process and Interactions, TERRA Teaching and Research Centre, University of Liege—Gembloux Agro-Bio Tech, 5030 Gembloux, Belgium;

[3] State key laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China;

关键词: Yarrowia lipolytica;    organic acids;    polyols;    sugar alcohols;   

DOI  :  10.3390/microorganisms8040574

来源: DOAJ

【 摘 要 】

Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms have a panoply of applications in agro-food, chemical and pharmaceutical industries. The main challenge in their production is to reach a productivity threshold that allow the process to be profitable. This relies on the construction of efficient cell factories by metabolic engineering and on the development of low-cost production processes by using industrial wastes or cheap and widely available raw materials as feedstock. The non-conventional yeast Yarrowia lipolytica has emerged recently as a potential producer of such metabolites owing its low nutritive requirements, its ability to grow at high cell densities in a bioreactor and ease of genome edition. This review will focus on current knowledge on the synthesis of the most important sugar alcohols and organic acids in Y. lipolytica.

【 授权许可】

Unknown