Intraoperative Radiation “Boost” to the Surgical Resection Bed following Pancreaticoduodenectomy for a Borderline Resectable Pancreatic Carcinoma: A Case Report

Frontiers in Oncology

卷:8

Tarita O. Thomas¹  William Small¹  Song Kang²  Mark Fleming⁵  Richard A. Hoefer⁶ 

[1] Cardinal Bernardin Cancer Center, Maguire Center, Loyola University Medical Center, Maywood, IL, United States;

[2] Department of Radiation Oncology, Sentara CarePlex Hospital, Sentara Healthcare, Hampton, VA, United States;

[3] Department of Radiation Oncology, Stritch School of Medicine, Loyola University, Chicago, IL, United States;

[4] Department of Surgical Oncology, Sentara CarePlex Hospital, Sentara Healthcare, Hampton, VA, United States;

[5] Division Chief Hematology and Oncology, Eastern Virginia Medical School, Norfolk, VA, United States;

[6] Eastern Virginia Medical School, Norfolk, VA, United States;

[7] Virginia Oncology Associates, Hampton, VA, United States;

关键词: intraoperative radiation therapy;    IORT;    pancreas cancer;    borderline resectable;    neoadjuvant therapy;   

DOI  :  10.3389/fonc.2018.00012

来源: DOAJ

【 摘 要 】

Neoadjuvant therapy including chemotherapy alone or concurrent chemotherapy with external bream radiation is a standard treatment strategy for borderline resectable pancreatic adenocarcinoma and is also used routinely for primary operable cancers at some institutions (1). The use of intraoperative radiation therapy (IORT) has been limited largely because of the logistical issues in delivery of radiation during surgery (2). This is the first reported case of a borderline resectable pancreas cancer patient who underwent neoadjuvant chemo-radiation therapy followed by resection with the use of IORT using the mobile IntraBeam device to boost the resection bed and improve local control by dose escalation.

【 授权许可】

Unknown