Prenatal Fine Particulate Matter, Maternal Micronutrient Antioxidant Intake, and Early Childhood Repeated Wheeze: Effect Modification by Race/Ethnicity and Sex

Antioxidants

卷:11

Brent A. Coull¹  Kecia N. Carroll²  Yueh-Hsiu Mathilda Chiu²  Rosalind J. Wright²  Ander Wilson³  Srimathi Kannan⁴ 

[1] Department of Biostatistics, Harvard TH Chan School of Public Health, Harvard University, Boston, MA 02115, USA;

[2] Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, P.O. Box 1057, New York, NY 10029, USA;

[3] Department of Statistics, Colorado State University, Fort Collins, CO 80523, USA;

[4] Division of Metabolism, Endocrinology and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48105, USA;

关键词: prenatal air pollution exposure;    childhood wheeze;    antioxidant intake;    race and ethnicity;    sex difference;    developmental origins of health and disease;   

DOI  :  10.3390/antiox11020366

来源: DOAJ

【 摘 要 】

Fine particulate matter (PM_2.5) potentiates in utero oxidative stress influencing fetal development while antioxidants have potential protective effects. We examined associations among prenatal PM_2.5, maternal antioxidant intake, and childhood wheeze in an urban pregnancy cohort (n = 530). Daily PM_2.5 exposure over gestation was estimated using a satellite-based spatiotemporally resolved model. Mothers completed the modified Block98 food frequency questionnaire. Average energy-adjusted percentile intake of β-carotene, vitamins (A, C, E), and trace minerals (zinc, magnesium, selenium) constituted an antioxidant index (AI). Maternal-reported child wheeze was ascertained up to 4.1 ± 2.8 years. Bayesian distributed lag interaction models (BDLIMs) were used to examine time-varying associations between prenatal PM_2.5 and repeated wheeze (≥2 episodes) and effect modification by AI, race/ethnicity, and child sex. Covariates included maternal age, education, asthma, and temperature. Women were 39% Black and 33% Hispanic, 36% with ≤high school education; 21% of children had repeated wheeze. Higher AI was associated with decreased wheeze in Blacks (OR = 0.37 (0.19–0.73), per IQR increase). BDLIMs identified a sensitive window for PM_2.5 effects on wheeze among boys born to Black mothers with low AI (at 33–40 weeks gestation; OR = 1.74 (1.19–2.54), per µg/m³ increase in PM_2.5). Relationships among prenatal PM_2.5, antioxidant intake, and child wheeze were modified by race/ethnicity and sex.

【 授权许可】

Unknown