Potential Uses of Olive Oil Secoiridoids for the Prevention and Treatment of Cancer: A Narrative Review of Preclinical Studies

International Journal of Molecular Sciences

卷:22

Vita Di Stefano¹  Giuseppe Montalto²  Giuseppa Augello²  Lydia Giannitrapani²  Melchiorre Cervello²  Maria Rita Emma²  Antonella Cusimano²  Antonina Azzolina² 

[1] Department of Biological, Chemical, and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, 90133 Palermo, Italy;

[2] Institute for Biomedical Research and Innovation, National Research Council (CNR), 90146 Palermo, Italy;

关键词: secoiridoids;    oleocanthal;    oleacein;    oleuropein;    ligstroside;    cancer;   

DOI  :  10.3390/ijms22031234

来源: DOAJ

【 摘 要 】

The Mediterranean diet (MD) is a combination of foods mainly rich in antioxidants and anti-inflammatory nutrients that have been shown to have many health-enhancing effects. Extra-virgin olive oil (EVOO) is an important component of the MD. The importance of EVOO can be attributed to phenolic compounds, represented by phenolic alcohols, hydroxytyrosol, and tyrosol, and to secoiridoids, which include oleocanthal, oleacein, oleuropein, and ligstroside (along with the aglycone and glycosidic derivatives of the latter two). Each secoiridoid has been studied and characterized, and their effects on human health have been documented by several studies. Secoiridoids have antioxidant, anti-inflammatory, and anti-proliferative properties and, therefore, exhibit anti-cancer activity. This review summarizes the most recent findings regarding the pharmacological properties, molecular targets, and action mechanisms of secoiridoids, focusing attention on their preventive and anti-cancer activities. It provides a critical analysis of preclinical, in vitro and in vivo, studies of these natural bioactive compounds used as agents against various human cancers. The prospects for their possible use in human cancer prevention and treatment is also discussed.

【 授权许可】

Unknown