The Emerging Role of Non-Coding RNAs in the Regulation of Virus Replication and Resultant Cellular Pathologies

International Journal of Molecular Sciences

卷:23

Hazha Hadayat Jamal¹  Soudeh Ghafouri-Fard²  Bashdar Mahmud Hussen³  Mohammad Taheri⁴  Guive Sharifi⁵ 

[1] Department of Biology, College of Education, Salahaddin University-Erbil, Erbil 44001, Iraq;

[2] Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 14155-6153, Iran;

[3] Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Erbil 44001, Iraq;

[4] Institute of Human Genetics, Jena University Hospital, Am Klinikum 1, 07747 Jena, Germany;

[5] Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran P.O. Box 14155-6153, Iran;

关键词: long non-coding RNA;    miRNA;    HSV;    EBV;    CMV;   

DOI  :  10.3390/ijms23020815

来源: DOAJ

【 摘 要 】

Non-coding RNAs, particularly lncRNAs and miRNAs, have recently been shown to regulate different steps in viral infections and induction of immune responses against viruses. Expressions of several host and viral lncRNAs have been found to be altered during viral infection. These lncRNAs can exert antiviral function via inhibition of viral infection or stimulation of antiviral immune response. Some other lncRNAs can promote viral replication or suppress antiviral responses. The current review summarizes the interaction between ncRNAs and herpes simplex virus, cytomegalovirus, and Epstein–Barr infections. The data presented in this review helps identify viral-related regulators and proposes novel strategies for the prevention and treatment of viral infection.

【 授权许可】

Unknown