Vitamin D and Skin Cancer: An Epidemiological, Patient-Centered Update and Review

Nutrients

卷:13

Yolanda Gilaberte¹  Eduardo Nagore²  Alejandro Martin-Gorgojo³ 

[1] Dermatology Department, Hospital Universitario Miguel Servet, IIS Aragon, 50009 Zaragoza, Spain;

[2] Dermatology Department, Universidad Catolica de Valencia, 46001 Valencia, Spain;

[3] STI/Dermatology Department, Madrid City Council, 28006 Madrid, Spain;

关键词: vitamin D;    vitamin D deficiency;    skin neoplasms;    melanoma;    cutaneous malignant melanoma;    basal cell carcinoma;   

DOI  :  10.3390/nu13124292

来源: DOAJ

【 摘 要 】

Background: The current vitamin D deficiency epidemic is accompanied by an increase in endemic skin cancer. There are still multiple controversies. This review aims to give practical recommendations regarding vitamin D among people at risk or with a personal history of skin cancer. Methods: Narrative review including human research articles published between 2011 and 2021, elaborated bearing in mind an epidemiological, patient-centered approach. Results: Ultraviolet (UV) exposure (neither artificial nor natural) is not the ideal source to synthesize vitamin D. There is conflicting epidemiological evidence regarding vitamin D, non-melanoma skin cancer (NMSC), and cutaneous melanoma (CMM), confounded by the effect of sun exposure and other factors. Conclusions: Current evidence is controversial, and there are no widely applicable strategies. We propose three practical recommendations. Firstly, sun protection recommendations should be kept among people at risk or with a personal history of skin cancer. Secondly, vitamin D should preferably be sourced through diet. In patients with melanoma or at risk of cutaneous cancer, serum vitamin D checks are warranted to detect and avoid its insufficiency.

【 授权许可】

Unknown