Pseudoneutropenia from cold agglutinin leucoagglutination

Journal of Clinical and Scientific Research

卷:4

Ingle A¹  Agarwal R¹  Momin M¹  Aluri A¹  Satyanarayana M¹  Quadri A¹  Yashovardhan A¹ 

[1] Yashoda Hospitals, Hyderabad;

关键词: Leucoagglutination;    Pseudoneutropenia;    Cold agglutinins;   

DOI  :  http://dx.doi.org/10.15380/2277-5706.JCSR.14.016

来源: DOAJ

【 摘 要 】

Pseudoneutropenia or low leucocyte count secondary to leucoagglutination is caused by ethylene diamine tetra aceticacid (EDTA) or cold agglutinins and is seen in benign and malignant disorders. We report a 34-year-old lady who wasadmitted with fever, vomiting, respiratory distress and productive cough. Complete blood count (CBC) at initial presentation revealed low haemoglobin (11.6 g/dL), total leucocyte count (TLC) (5900/mm3 ) with 50% polymorphs. Peripheral blood smear showed leucocytes in clusters. Another sample was asked for in citrate anticoagulant which showed a TLC of 5900/mm3 with 50% polymorphs and evidence of auto agglutination. Another collected in a prewarmed ethylene diamine tetra acetic acid (EDTA) tube, CBC showed a TLC of 9800/mm3 with 39% neutrophils suggestive of pseudoneutropenia due to cold agglutinins.

【 授权许可】

Unknown