Long-term exposure to PM10 and NO2 in relation to lung function and imaging phenotypes in a COPD cohort

Respiratory Research

卷:21

Sung Ok Kwon¹  Sun-Young Kim²  Young-Ji Han³  Seok Ho Hong⁴  Woo Jin Kim⁴  So Hyeon Bak⁵  Junghyun Kim⁶  Mi Kyeong Lee⁷  Stephanie J. London⁷ 

[1] Biomedical Research Institutue, Kangwon National University Hospital;

[2] Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center;

[3] Department of Environmental Science, Kangwon National University;

[4] Department of Internal Medicine and Environemntal Health Center, Kangwon National University;

[5] Department of Radiology, School of Medicine, Kangwon National University;

[6] Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center;

[7] National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services;

关键词: Air pollution;    COPD;    CT;    Lung function;    Traffic;   

DOI  :  10.1186/s12931-020-01514-w

来源: DOAJ

【 摘 要 】

Abstract Background Ambient air pollution can contribute to the development and exacerbation of COPD. However, the influence of air pollution on objective COPD phenotypes, especially from imaging, is not well studied. We investigated the influence of long-term exposure to air pollution on lung function and quantitative imaging measurements in a Korean cohort of participants with and without COPD diagnosis. Methods Study participants (N = 457 including 296 COPD cases) were obtained from the COPD in Dusty Areas (CODA) cohort. Annual average concentrations of particulate matter less than or equal to 10 μm in diameter (PM10) and nitrogen dioxide (NO2) were estimated at the participants’ residential addresses using a spatial air pollution prediction model. All the participants underwent volumetric computerized tomography (CT) and spirometry measurements and completed survey questionnaires. We examined the associations of PM10 and NO2 with FVC, FEV1, emphysema index, and wall area percent, using linear regression models adjusting for age, gender, education, smoking, height, weight, and COPD medication. Results The age of study participants averaged 71.7 years. An interquartile range difference in annual PM10 exposure of 4.4 μg/m3 was associated with 0.13 L lower FVC (95% confidence interval (CI), − 0.22- -0.05, p = 0.003). Emphysema index (mean = 6.36) was higher by 1.13 (95% CI, 0.25–2.02, p = 0.012) and wall area percent (mean = 68.8) was higher by 1.04 (95% CI, 0.27–1.80, p = 0.008). Associations with imaging phenotypes  were not observed with NO2. Conclusions Long-term exposure to PM10 correlated with both lung function and COPD-relevant imaging phenotypes in a Korean cohort.

【 授权许可】

Unknown