Competing Endogenous RNAs in Cervical Carcinogenesis: A New Layer of Complexity

Processes

卷:9

Jong Kook Park¹  Karen Brajão de Oliveira²  Danielle Malheiros³  Fernanda Costa Brandão Berti³  Patrícia Savio de Araújo-Souza³  Amanda Salviano-Silva³  Gabriel Adelman Cipolla³  Camila de Freitas Oliveira-Toré⁴  Sara Cristina Lobo-Alves⁵ 

[1] Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University, Chuncheon 24252, Korea;

[2] Postgraduate Program in Experimental Pathology, Department of Pathological Sciences, Londrina State University, Londrina 86057-970, Brazil;

[3] Postgraduate Program in Genetics, Department of Genetics, Federal University of Paraná, Curitiba 81531-990, Brazil;

[4] Postgraduate Program in Internal Medicine, Department of Internal Medicine, Federal University of Paraná, Curitiba 81531-990, Brazil;

[5] Research Institute Pelé Pequeno Príncipe, Curitiba 80250-060, Brazil;

关键词: long noncoding RNA;    microRNA;    mRNA;    competing endogenous RNA;    cervical cancer;   

DOI  :  10.3390/pr9060991

来源: DOAJ

【 摘 要 】

MicroRNAs (miRNAs) regulate gene expression by binding to complementary sequences within target mRNAs. Apart from working ‘solo’, miRNAs may interact in important molecular networks such as competing endogenous RNA (ceRNA) axes. By competing for a limited pool of miRNAs, transcripts such as long noncoding RNAs (lncRNAs) and mRNAs can regulate each other, fine-tuning gene expression. Several ceRNA networks led by different lncRNAs—described here as lncRNA-mediated ceRNAs—seem to play essential roles in cervical cancer (CC). By conducting an extensive search, we summarized networks involved in CC, highlighting the major impacts of such dynamic molecular changes over multiple cellular processes. Through the sponging of distinct miRNAs, some lncRNAs as HOTAIR, MALAT1, NEAT1, OIP5-AS1, and XIST trigger crucial molecular changes, ultimately increasing cell proliferation, migration, invasion, and inhibiting apoptosis. Likewise, several lncRNAs seem to be a sponge for important tumor-suppressive miRNAs (as miR-140-5p, miR-143-3p, miR-148a-3p, and miR-206), impairing such molecules from exerting a negative post-transcriptional regulation over target mRNAs. Curiously, some of the involved mRNAs code for important proteins such as PTEN, ROCK1, and MAPK1, known to modulate cell growth, proliferation, apoptosis, and adhesion in CC. Overall, we highlight important lncRNA-mediated functional interactions occurring in cervical cells and their closely related impact on cervical carcinogenesis.

【 授权许可】

Unknown