Humoral Immunity against Measles in Mother–Infant Pairs during the First Year of Life in Greece: A Cross-Sectional Study

Vaccines

卷:9

Evangelia Farmaki¹  Styliani Glykou¹  Fotiοs Papachristou¹  Anna Taparkou¹  Eleni Agakidou¹  Eleni Papadimitriou¹  Florentia Kanakoudi-Tsakalidou¹ 

[1] Department of Pediatrics, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateion General Hospital, 49 Konstantinoupoleos Str, P.C. 54246 Thessaloniki, Greece;

关键词: maternal-infant measles immunity;    measles antibodies;    waning measles immunity;    vaccine-induced immunity;    measles susceptible infants;    measles passive immunity;   

DOI  :  10.3390/vaccines9020143

来源: DOAJ

【 摘 要 】

Measles outbreaks have surfaced in Europe during the last decades. Infants <12 months of age were the most severely affected pediatric population. The aim of this study was to investigate the duration of maternally derived measles antibodies in infants aged 1 to 12 months in relation to maternal humoral immune status and other parameters. In a prospective, cross-sectional cohort study, 124 mother/infant pairs and 63 additional infants were recruited from October 2015 through December 2019. Infants were hospitalized in a university pediatric department of a general hospital. Demographic and epidemiological data were recorded and blood samples were collected from mothers and their infants. Commercially available enzyme-linked immunosorbent assay (ELISA) was used for measuring measles antibodies. Fifty nine percent of mothers had vaccine-induced and 15% infection-acquired measles immunity. Eighty-eight percent and 94% of infants were unprotected by 5 and 10 months of age, respectively. Maternal antibody levels and infant age were significant independent predictors of infants’ antibody levels whereas the method of maternal immunity acquisition, age, and origin [Greek/non-Greek] were not. Our findings suggest that about 90% of infants are susceptible to measles beyond the age of 4 months. To our knowledge, these are the first data from Greece reported under the current community composition and epidemiological conditions.

【 授权许可】

Unknown