Proton magnetic resonance spectroscopy as an alternative method for quantitative assessment of mineral bone density

Alʹmanah Kliničeskoj Mediciny

卷:49

D. A. Kupriyanov¹  U. A. Polyakova²  A. V. Manzhurtsev³  T. A. Akhadov⁴  A. S. Ivantsova⁴  N. A. Semenova⁴  P. E. Menshchikov⁴  M. V. Ublinskiy⁴ 

[1] Emanuel Institute of Biochemical Physics of Russian Academy of Sciences;

[2] N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences;

[3] Philips Healthcare LLC;

[4] Clinical and Research Institute of Emergency Pediatric Surgery and Trauma;

关键词: osteoporosis;    bone mineral density;    fat fraction;    localized proton magnetic resonance spectroscopy;   

DOI  :  10.18786/2072-0505-2021-49-002

来源: DOAJ

【 摘 要 】

Aims: 1) To evaluate an association between the fat fraction (FF) and bone mineral density (BMD) measured by localized proton magnetic resonance spectroscopy (1H-MRS) and quantitative computed tomography (QCT) densitometry, respectively, in healthy vertebrae of children after a compression fracture; 2) To compare the FF and BMD values with the severity of the compression vertebrae fractures.Materials and methods: Twenty (20) patients (aged 11.1±2.1 years) with a trauma-induced compression vertebral fractures participated in the study. The BMD of L3, L4 vertebrae (mg/cm3) was measured in by QCT (Philips Brilliance 16). FF in the same area was measured from 1H-MR-spectra (STEAM, echo time (TE)=12.8 ms, repetition time (TR)=3000 ms, voxel size=20×15×10 mm) using Philips Achieva TX 3.0T MRI scanner.Results: Correlation analysis revealed a  significant inverse linear correlation (r=-0.55, p=0.0004) between FF and BMD of L3 и L4 vertebrae. In addition, in the patients with severe compression vertebral fracture (more than 2 fractured vertebrae) there was a  significant increase in FF values and a  BMD decrease, compared to the values in the patients with mild fractures (1–2 fractured vertebrae).Conclusion: The correlation suggests that the increase of FF in the bone marrow and the decrease of BMD in children go in parallel. Therefore, 1H-MRS could be an alternative to QCT and dual-energy X-ray absorptiometry. The absence of radiation load allows for recommendation to use 1Н-MRS for screening and follow-up, as well as for the control of BMD.

【 授权许可】

Unknown