Folic acid-functionalized tea polyphenol as a tumor-targeting nano-drug delivery system

Materials & Design

卷:206

Haifeng Chen¹  Jinglun Li²  Na Zhao³  Gang Guo³  Aiping Tong⁴  Huan Hou⁴  Min Mu⁴  Bo Han⁴  Di Chuan⁴  Bingwen Zou⁴ 

[1] Corresponding authors.;

[2] Department of Neurology, the Affiliated Hospital of Southwest Medical University, Luzhou 646000, China;

[3] School of Pharmacy, Shihezi University, and Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi 832002, China;

[4] State Key Laboratory of Biotherapy and Cancer Center, and Department of Neurosurgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China;

关键词: Polyphenol;    Ovarian Cancer;    Folic Acid;    Epigallocatechin Gallate;    Nano-drug delivery system;   

DOI  :  

来源: DOAJ

【 摘 要 】

Epigallocatechin Gallate (EGCG) is the main component of green tea which can strongly bind to proteins, small molecular drugs, and DNA. Therefore, EGCG can be used to deliver biomacromolecules and drugs. In this study, a doxorubicin (DOX) delivery system (FPE/DOX NPs) based on the folic acid-functionalized EGCG was developed for the targeting therapy of ovarian cancer. Cellular uptake studies showed that FPE/DOX NPs enhanced DOX uptake by SKOV3 cells compared with PE/DOX NPs that without folic acid modification. In vitro, the toxicity of FPE/DOX NPs to SKOV3 cells was stronger than nanoparticles without folic acid modification. In vivo, the SKOV3 tumor growth inhibition effect of FPE/DOX NPs was substantially more effective than other groups. Together, the results of this study suggested that FPE/DOX NPs may have promising applications in ovarian cancer therapy.

【 授权许可】

Unknown