The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders

Biomedicine & Pharmacotherapy

卷:138

Bashdar M. Hussen¹  Mohammad Taheri²  Hamed Shoorei³  Afete Abak⁴  Soudeh Ghafouri-Fard⁵  Zahra Bahroudi⁶  Faranak Fattahi⁷ 

[1] Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158, USA;

[2] Department of Anatomical Sciences, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran;

[3] Department of Anatomical Sciences, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;

[4] Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;

[5] Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran;

[6] Department of Pharmacognosy, College of Pharmacy, Hawler Medical University, Kurdistan Region, Erbil, Iraq;

[7] Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143, USA;

关键词: MiRNA;    LncRNA;    Nuclear factor-κB;    NF-κB;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nuclear factor-κB (NF-κB) represents a group of inducible transcription factors (TFs) regulating the expression of a great variety of genes implicated in diverse processes, particularly modulation of immune system responses. This TF has functional interactions with non-coding RNAs, constructing a complicated network through which NF-κB, miRNAs, and lncRNAs coordinately regulate gene expression at different facets. This type of interaction is involved in the pathophysiology of several human disorders including both neoplastic disorders and non-neoplastic conditions. MALAT1 and NKILA are among lncRNAs whose interactions with NF-κB have been vastly assessed in different conditions including cancer and inflammatory conditions. In addition, miR-146a/b has functional interactions with this TF in different contexts. Although miRNAs have mutual interactions with NF-κB, the regulatory role of miRNAs on this TF has been more clarified. The aim of the current review is to explore the function of NF-κB-related miRNAs and lncRNAs in these two types of human disorders.

【 授权许可】

Unknown