New insight into inter-organ crosstalk contributing to the pathogenesis of non-alcoholic fatty liver disease (NAFLD)

Protein & Cell

卷:9

John Zhong Li¹  Xuetao Ji¹  Xu Zhang¹  Qian Wang¹ 

[1] Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Nanjing Medical University;

关键词: non-alcoholic fatty liver disease;    hepatic lipid metabolism;    hypothalamus;    gut-liver axis;    adipose tissue;   

DOI  :  10.1007/s13238-017-0436-0

来源: DOAJ

【 摘 要 】

ABSTRACT Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a significant global health problem with substantial rise in prevalence over the last decades. It is becoming increasingly clear that NALFD is not only predominantly a hepatic manifestation of metabolic syndrome, but also involves extra-hepatic organs and regulatory pathways. Therapeutic options are limited for the treatment of NAFLD. Accordingly, a better understanding of the pathogenesis of NAFLD is critical for gaining new insight into the regulatory network of NAFLD and for identifying new targets for the prevention and treatment of NAFLD. In this review, we emphasize on the current understanding of the inter-organ crosstalk between the liver and peripheral organs that contributing to the pathogenesis of NAFLD.

【 授权许可】

Unknown