Long‐Term Survival of Patients With Left Ventricular Noncompaction

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

卷:10

David O. Hodge¹  Medhat Farwati²  Suraj Kapa²  Melissa Lyle²  Sri Harsha Patlolla²  Hector I. Michelena²  Heidi M. Connolly²  Samuel J. Asirvatham²  William R. Miranda²  Ameesh Isath²  Vaibhav R. Vaidya²  Rowlens M. Melduni²  Abhishek J. Deshmukh²  Thomas A. Foley³ 

[1]Department of Cardiovascular Diseases Mayo Clinic Jacksonville FL

[2]|Department of Cardiovascular Diseases Mayo Clinic Rochester MN

[3]|Department of Radiology Mayo Clinic Rochester MN

关键词: ejection fraction;    mortality;    noncompaction;    prognosis;    survival;   

DOI  :  10.1161/JAHA.119.015563

来源: DOAJ

【 摘 要 】

Background The prognosis of left ventricular noncompaction (LVNC) remains elusive despite its recognition as a clinical entity for >30 years. We sought to identify clinical and imaging characteristics and risk factors for mortality in patients with LVNC. Methods and Results 339 adults with LVNC seen between 2000 and 2016 were identified. LVNC was defined as end‐systolic noncompacted to compacted myocardial ratio >2 (Jenni criteria) and end‐diastolic trough of trabeculation‐to‐epicardium (X):peak of trabeculation‐to‐epicardium (Y) ratio <0.5 (Chin criteria) by echocardiography; and end‐diastolic noncompacted:compacted ratio >2.3 (Petersen criteria) by magnetic resonance imaging. Median age was 47.4 years, and 46% of patients were female. Left ventricular ejection fraction <50% was present in 57% of patients and isolated apical noncompaction in 48%. During a median follow‐up of 6.3 years, 59 patients died. On multivariable Cox regression analysis, age (hazard ratio [HR] 1.04; 95% CI, 1.02–1.06), left ventricular ejection fraction <50% (HR, 2.37; 95% CI, 1.17–4.80), and noncompaction extending from the apex to the mid or basal segments (HR, 2.11; 95% CI, 1.21–3.68) were associated with all‐cause mortality. Compared with the expected survival for age‐ and sex‐matched US population, patients with LVNC had reduced overall survival (P<0.001). However, patients with LVNC with preserved left ventricular ejection fraction and patients with isolated apical noncompaction had similar survival to the general population. Conclusions Overall survival is reduced in patients with LVNC compared with the expected survival of age‐ and sex‐matched US population. However, survival rate in those with preserved left ventricular ejection fraction and isolated apical noncompaction was comparable with that of the general population.

【 授权许可】

Unknown