Fibroblast Growth Factor 1 Ameliorates Diabetes-Induced Liver Injury by Reducing Cellular Stress and Restoring Autophagy

Frontiers in Pharmacology

卷:11

Fan Wang¹  Yanlong Liu²  Longteng Xie³  Xie Zhang⁴  Yanqing Wu⁵  Xindian Pan⁶  Ting Jiang⁷  Yuying Li⁷  Ping Wang⁷  Yiyang Li⁷  Jian Xiao⁷  Zeping Xu⁷  Junnan Wu⁷  Xiaofeng Li⁷ 

[1] Beijing Hui-Long-Guan Hospital, Peking University, Beijing, China;

[2] Center for Health Assessment, Wenzhou Medical University, Wenzhou, China;

[3] Department of Infection Diseases, Ningbo Fourth Hospital, Xiangshan, China;

[4] Department of Pharmacy, Ningbo Medical Treatment Center, Li Huili Hospital, Ningbo, China;

[5] Institute of Life Sciences, Wenzhou University, Wenzhou, China;

[6] School of Medicine, Hangzhou Normal University, Hangzhou, China;

[7] School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China;

[8] The Second Affiliated Hospital, Xinjiang Medical University, Urumqi, China;

关键词: fibroblast growth factor 1;    diabetes;    liver injury;    oxidative stress;    endoplasmic reticulum stress;   

DOI  :  10.3389/fphar.2020.00052

来源: DOAJ

【 摘 要 】

BackgroundType 2 diabetes (T2D) is a metabolic dysfunction disease that causes several complications. Liver injury is one of these that severely affects patients with diabetes. Fibroblast growth factor 1 (FGF1) has glucose-lowering activity and plays a role in modulation of several liver injuries. Nevertheless, the effects and potential mechanisms of FGF1 against diabetes-induced liver injury are unknown.MethodsTo further investigate the effect of FGF1 on diabetic liver injury, we divided db/db mice into two groups and intraperitoneally (i.p.) injected either with FGF1 at 0.5 mg/kg body weight or saline every other day for 4 weeks. Then body weights were measured. Serum and liver tissues were collected for biochemical and molecular analyses.ResultsFGF1 significantly reduced blood glucose and ameliorated diabetes-induced liver steatosis, fibrosis, and apoptosis. FGF1 also restored defective hepatic autophagy in db/db mice. Mechanistic investigations showed that diabetes markedly induced oxidative stress and endoplasmic reticulum stress and that FGF1 treatment significantly attenuated these effects.ConclusionsFGF1-associated glucose level reduction and amelioration of cellular stress are potential protective effects of FGF1 against diabetes-induced liver injury.

【 授权许可】

Unknown