The Role, Involvement and Function(s) of Interleukin-35 and Interleukin-37 in Disease Pathogenesis

International Journal of Molecular Sciences

卷:19

Zainul Amiruddin Zakaria¹  Mohd Khairi Hussain¹  Rusliza Basir²  Mohammad Faruq Abd Rachman Isnadi²  Ramatu Omenesa Bello²  Roslaini Abd Majid³  Voon Kin Chin³  Maizaton Atmadini Abdullah⁴  Tze Yan Lee⁴ 

[1] Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia;

[2] Department of Human Anatomy, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia;

[3] Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia;

[4] Department of Pathology, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia;

关键词: cytokines;    interleukin-35;    interleukin-37;    pathogenesis;   

DOI  :  10.3390/ijms19041149

来源: DOAJ

【 摘 要 】

The recently identified cytokines—interleukin (IL)-35 and interleukin (IL)-37—have been described for their anti-inflammatory and immune-modulating actions in numerous inflammatory diseases, auto-immune disorders, malignancies, infectious diseases and sepsis. Either cytokine has been reported to be reduced and in some cases elevated and consequently contributed towards disease pathogenesis. In view of the recent advances in utilizing cytokine profiles for the development of biological macromolecules, beneficial in the management of certain intractable immune-mediated disorders, these recently characterized cytokines (IL-35 and IL-37) offer potential as reasonable targets for the discovery of novel immune-modulating anti-inflammatory therapies. A detailed comprehension of their sophisticated regulatory mechanisms and patterns of expression may provide unique opportunities for clinical application as highly selective and target specific therapeutic agents. This review seeks to summarize the recent advancements in discerning the dynamics, mechanisms, immunoregulatory and anti-inflammatory actions of IL-35 and IL-37 as they relate to disease pathogenesis.

【 授权许可】

Unknown