Mammalian yolk sac - an alternative source of stem cells

Brazilian Journal of Veterinary Medicine

卷:43

Vanessa CristinaOliveira¹  Luciana CristinaMachado¹  Lina Castelo BrancoMotta²  Priscilla Avelino FerreiraPinto³  Tiago Gonçalvesdos Santos⁴  Matheus Ferreirade Almeida⁴  Vitória MattosPereira⁴  Carlos EduardoAmbrósio⁵ 

[1] Biologist, DSc, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, São Paulo, Brazil;

[2] Biologist, MSc, Criocord - Banco de Sangue de Cordão Umbilical e Placentário, Fortaleza, Ceará, Brazil;

[3] Physiotherapist, MSc, Departamento de Cirurgia, Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo (USP), São Paulo, SP, Brazil;

[4] Undergaduate in Veterinary Medicine, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, São Paulo, Brazil;

[5] Veterinarian, DSc, Departamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, USP, Pirassununga, São Paulo, Brazil;

关键词: mesenchymal stem cells, hematopoietic stem cells, placenta development, fetal membranes.;   

DOI  :  10.29374/2527-2179.bjvm001221

来源: DOAJ

【 摘 要 】

Fetal tissue-derived stem cells have been the subject of several studies. Among them, the yolk sac (YS) nourishes the embryo, synthesizes proteins and vitamins, and is the first hematopoietic site of the embryo. Stem cells derived from the YS can benefit several animal species as therapies aimed at tissue regeneration and immunological diseases. This review aims to describe the development, function, and possible dysfunctions of YS in different species, and consolidate the findings presented in the literature on the isolation, culture, and application of YS-derived stem cells from different mammals in regenerative medicine. Hematopoietic and mesenchymal stem cells have been previously investigated in the YS of different mammals; however, the culture media and isolation protocols differ between species. To date, no studies have been conducted using stem cells derived from the YS for cell therapy. Nevertheless, several domestic mammals have shown cellular markers characteristic of mesenchymal stem cells derived from the YS.

【 授权许可】

Unknown