The Impact of Milk and Its Components on Epigenetic Programming of Immune Function in Early Life and Beyond: Implications for Allergy and Asthma

Frontiers in Immunology

卷:11

Suzanne Abbring¹  R. J. Joost van Neerven¹  Mojtaba Porbahaie²  Betty C. A. M. van Esch³  Johan Garssen⁴  Daniel P. Potaczek⁵  Huub F. J. Savelkoul⁶ 

[1] Research, Wageningen, Netherlands;

[2] Cell Biology and Immunology Group, Wageningen University &

[3] Danone Nutricia Research, Utrecht, Netherlands;

[4] Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands;

[5] Institute of Laboratory Medicine, Member of the German Center for Lung Research (DZL), The Universities of Giessen and Marburg Lung Center (UGMLC), Philipps-University Marburg, Marburg, Germany;

[6] John Paul II Hospital, Krakow, Poland;

关键词: epigenetics;    epigenetic imprinting;    environmental factors;    unprocessed (raw) milk;    breastfeeding;    allergy;   

DOI  :  10.3389/fimmu.2020.02141

来源: DOAJ

【 摘 要 】

Specific and adequate nutrition during pregnancy and early life is an important factor in avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular disease, cancers, and chronic allergic diseases. Although epidemiologic and experimental studies have shown that nutrition is important at all stages of life, it is especially important in prenatal and the first few years of life. During the last decade, there has been a growing interest in the potential role of epigenetic mechanisms in the increasing health problems associated with allergic disease. Epigenetics involves several mechanisms including DNA methylation, histone modifications, and microRNAs which can modify the expression of genes. In this study, we focus on the effects of maternal nutrition during pregnancy, the effects of the bioactive components in human and bovine milk, and the environmental factors that can affect early life (i.e., farming, milk processing, and bacterial exposure), and which contribute to the epigenetic mechanisms underlying the persistent programming of immune functions and allergic diseases. This knowledge will help to improve approaches to nutrition in early life and help prevent allergies in the future.

【 授权许可】

Unknown