Orbitofrontal cortex grey matter volume is related to children’s depressive symptoms

NeuroImage: Clinical

卷:28

Pan Liu¹  Elizabeth P. Hayden²  Ola Mohamed Ali³  Andrew R. Daoust³  Marc F. Joanisse³  Deanna M. Barch³  Matthew R.J. Vandermeer³ 

[1] Corresponding author at: Department of Psychology, The Brain and Mind Institute, Western University, Western Interdisciplinary Research Building, Room 3190, 1151 Richmond St., London, ON N6A 3K7, Canada.;

[2] Department of Psychiatry, Washington University School of Medicine, 4444 Forest Park Avenue, Suite 2100, St. Louis, MO, USA;

[3] Department of Psychology, The Brain and Mind Institute, Western University, Western Interdisciplinary Research Building, Room 3190, 1151 Richmond St., London, ON N6A 3K7, Canada;

关键词: Voxel-based morphometry;    Depression;    Orbitofrontal cortex;    Children;    Reward;   

DOI  :  

来源: DOAJ

【 摘 要 】

Adults with a history of depression show distinct patterns of grey matter volume (GMV) in frontal cortical (e.g., prefrontal cortex, orbitofrontal cortex) and limbic (e.g., anterior cingulate, amygdala, hippocampus, dorsal striatum) structures, regions relevant to the processing and regulation of reward, which is impaired in the context of depression. However, it is unclear whether these GMV associations with depression precede depressive disorder onset or whether GMV is related to early emerging symptoms or familial depression. To address these questions, we used voxel-based morphometry (VBM) to examine GMV in 85 community-dwelling children (M = 11.12 years, SD = 0.63 years) screened for current and lifetime depression. Associations between children’s depressive symptoms (self- and mother-report of children’s symptoms), children’s maternal depression history, and GMV were examined. Although maternal depression history was unrelated to children’s GMV, child GMV in the orbitofrontal cortex (OFC) was negatively related to children’s self-reported depressive symptoms, using both a priori ROI and whole-brain analyses. Moderated regression analyses indicated that girls’ GMV was negatively related to girls’ depressive symptoms (as indexed by both self- and mother-report of girls’ symptoms), whereas boys’ symptoms were positively related to GMV. Our findings suggest that brain morphology in the OFC, a region with functional roles in processes relevant to depressive symptoms (i.e., reward-based learning and reward processing), is associated with early depressive symptoms prior to the development of clinically significant depression.

【 授权许可】

Unknown