The role of limbic structures in financial abilities of mild cognitive impairment patients

NeuroImage: Clinical

卷:26

Micaela Mitolo¹  Francesca Burgio²  Carlo Semenza³  Silvia Benavides-Varela⁴  Giorgio Arcara⁵  Roberta Toffano⁶  Dante Mantini⁷  Katie Palmer⁷  Luca Weis⁷  Antonino Vallesi⁷  Francesca Meneghello⁷ 

[1] Corresponding author.;

[2] Department of General Psychology, University of Padova, Padova, Italy;

[3] Department of Neuroscience and Padova Neuroscience Center, University of Padova, Padova, Italy;

[4] Department of Developmental Psychology and Socialisation, University of Padova, Padova, Italy;

[5] Department of Geriatrics, Centro Medicina dell'Invecchiamento, Università Cattolica del Sacro Cuore, Rome, Italy;

[6] IRCCS Istituto delle Scienze Neurologiche di Bologna, Programma Neuroimmagini Funzionali e Molecolari, Bologna, Italy;

[7] IRCCS San Camillo Hospital, Venice, Italy;

关键词: MCI;    Alzheimer's disease;    Pathological aging;    Financial decisions;    VBM;    Everyday functioning;   

DOI  :  

来源: DOAJ

【 摘 要 】

Mild Cognitive Impairment (MCI) patients experience problems in financial abilities that affect everyday functioning. To date, the neural correlates of decline in this domain are unclear. This study aims at examining the correlation between the pattern of brain atrophy of MCI patients and performance on financial abilities. Forty-four MCI patients and thirty-seven healthy controls underwent structural magnetic resonance imaging, and assessment of financial abilitiesby means of the Numerical Activities of Daily Living Financial battery (NADL-F). As compared to healthy controls, MCI patients showed impaired performance in three out of the seven domains assessed by NADL-F: Item purchase, percentage, and financial concepts. The patients’ performance in the NADL-F correlated with memory, language, visuo-spatial, and abstract reasoning composite scores. The analysis also revealed that volumetric differences in the limbic structures significantly correlated with financial abilities in MCI. Specifically, the patients’ performance in the NADL-F was correlated with atrophy in the left medial and lateral amygdala and the right anterior thalamic radiation. These findings suggest that completing daily financial tasks involves sub-cortical regions in MCI and presumably also the motivational and emotional processes associated to them. Involvement of altered limbic structures in MCI patients suggests that impairment in financial abilities may be related to emotional and reflexive processing deficits.

【 授权许可】

Unknown