Pseudomembranous colitis in a patient with lamotrigine-induced drug rash with eosinophilia and systemic symptoms syndrome

Gastroenterology Insights

卷:7

Eduardo Martín Nares¹  Alvaro López Iñiguez¹  Sandra Gónzalez Saldaña¹  Manuel Soria Orozco¹  Lorena Valerdi Contreras¹  Jair Abdiel Toro Guerrero² 

[1] Department of Internal Medicine, Civil Hospital Fray Antonio Alcalde, Guadalajara, Jalisco;

[2] Department of Pathology, Civil Hospital Fray Antonio Alcalde, Guadalajara, Jalisco;

关键词: DRESS syndrome;    multiorgan involvement;    pseudomembranous colitis;    lamotrigine;    anticonvulsant hypersensitivity syndrome;   

DOI  :  10.4081/gi.2016.6491

来源: DOAJ

【 摘 要 】

Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a hypersensitivity reaction with rash, fever and multiorgan dysfunction potentially lethal in up to 10% of cases. It often affects liver function, but it can also affect kidney, lungs, and heart. Severe gastrointestinal involvement is rare. We present a case of a 31-year-old hispanic woman with pseudomembranous colitis associated with lamotrigine-induced DRESS syndrome. To the best of our knowledge, this is the fourth reported case of severe involvement of the gastrointestinal tract and the first to report pseudomembranous colitis in the setting of DRESS syndrome.

【 授权许可】

Unknown