Emerging Nano-Based Strategies Against Drug Resistance in Tumor Chemotherapy

Frontiers in Bioengineering and Biotechnology

卷:9

Weiju Wang¹  Lei Cao²  Gaoxiong Wang²  Yuqin Zhu²  Shuaishuai Zhang³  Hongwei Cheng⁴ 

[1] Department of Pathology, Qingyuan Maternal and Child Health Hospital, Qingyuan, China;

[2] Department of Pathology, Quanzhou Women’s and Children’s Hospital, Quanzhou, China;

[3] School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, China;

[4] State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, China;

关键词: tumor chemotherapy;    drug resistance;    tumor microenvironment;    nanomedical strategy;    combination therapy;   

DOI  :  10.3389/fbioe.2021.798882

来源: DOAJ

【 摘 要 】

Drug resistance is the most significant causes of cancer chemotherapy failure. Various mechanisms of drug resistance include tumor heterogeneity, tumor microenvironment, changes at cellular levels, genetic factors, and other mechanisms. In recent years, more attention has been paid to tumor resistance mechanisms and countermeasures. Nanomedicine is an emerging treatment platform, focusing on alternative drug delivery and improved therapeutic effectiveness while reducing side effects on normal tissues. Here, we reviewed the principal forms of drug resistance and the new possibilities that nanomaterials offer for overcoming these therapeutic barriers. Novel nanomaterials based on tumor types are an excellent modality to equalize drug resistance that enables gain more rational and flexible drug selectivity for individual patient treatment. With the emergence of advanced designs and alternative drug delivery strategies with different nanomaterials, overcome of multidrug resistance shows promising and opens new horizons for cancer therapy. This review discussed different mechanisms of drug resistance and recent advances in nanotechnology-based therapeutic strategies to improve the sensitivity and effectiveness of chemotherapeutic drugs, aiming to show the advantages of nanomaterials in overcoming of drug resistance for tumor chemotherapy, which could accelerate the development of personalized medicine.

【 授权许可】

Unknown