Chemokine Signaling in Chemotherapy-Induced Neuropathic Pain

International Journal of Molecular Sciences

卷:20

Annamaria Cimini¹  Michele d’Angelo¹  Andrea Antonosante¹  Laura Brandolini²  Marcello Allegretti² 

[1] Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy;

[2] Dompé Farmaceutici SpA, Via Campo di Pile,67100 L’Aquila, Italy;

关键词: chemotherapy;    peripheral nervous system;    central nervous system;    inflammatory mediators;    cytokines;    chemokines;   

DOI  :  10.3390/ijms20122904

来源: DOAJ

【 摘 要 】

Chemotherapy-induced peripheral neuropathy (CIPN) is a side effect of chemotherapics such as taxanes, vinca alkaloids, and platinum compounds. In recent years, several reports have indicated the involvement of different molecular mechanisms in CIPN. The pathways described so far are diverse and target various components of the peripheral Nervous System (PNS). Among the contributors to neuropathic pain, inflammation has been indicated as a powerful driver of CIPN. Several pieces of evidence have demonstrated a chemotherapy-induced increase in peripheral pro-inflammatory cytokines and a strong correlation with peripheral neuropathy. At present, there are not adequate strategies to prevent CIPN, although there are drugs for treating CIPN, such as duloxetine, that have displayed a moderate effect on CIPN. In this review, we focus on the players involved in CIPN with a particular emphasis on chemokine signaling.

【 授权许可】

Unknown