X chromosome inactivation: new players in the initiation of gene silencing [version 1; referees: 2 approved]

F1000Research

卷:6

Ines Pinheiro¹  Edith Heard¹ 

[1] Mammalian Developmental Epigenetics Group (équipe labellisée La Ligue), Institut Curie, PSL Research University, CNRS UMR3215, INSERM U934, 26 Rue d’Ulm, 11 75248 Paris Cedex 05, France;

关键词: Biomacromolecule-Ligand Interactions;    Control of Gene Expression;    Evolutionary/Comparative Genetics;    Genomics;    Nuclear Structure & Function;    Structure: RNA;   

DOI  :  10.12688/f1000research.10707.1

来源: DOAJ

【 摘 要 】

X chromosome inactivation (XCI) is a dosage compensation process that was adopted by female mammals to balance gene dosage between XX females and XY males. XCI starts with the upregulation of the non-coding RNA Xist, after which most X-linked genes are silenced and acquire a repressive chromatin state. Even though the chromatin marks of the inactive X have been fairly well described, the mechanisms responsible for the initiation of XCI remain largely unknown. In this review, we discuss recent developments that revealed unexpected factors playing a role in XCI and that might be of crucial importance to understand the mechanisms responsible for the very first steps of this chromosome-wide gene-silencing event.

【 授权许可】

Unknown