Risk factors for severe radiation-induced oral mucositis in patients with oral cancer

Journal of Dental Sciences

卷:16

Mika Nishii¹  Souichi Yanamoto²  Takumi Hasegawa³  Masahiro Umeda⁴  Sakiko Soutome⁴  Yuka Kojima⁵  Toshiyuki Saito⁵  Madoka Funahara⁵  Masaya Akashi⁶ 

[1] Corresponding author. Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8588, Japan.;

[2] Department of Clinical Oral Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;

[3] Department of Dentistry and Oral Surgery, Kansai Medical University, Osaka, Japan;

[4] Department of Oral Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan;

[5] Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan;

[6] Kyushu Dental University School of Oral Health, Kitakyushu, Japan;

关键词: Oral mucositis;    Radiotherapy;    Oral cancer;    Pilocarpine;    Risk factors;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background/purpose: Radiotherapy for head and neck cancer often causes severe oral mucositis. The purpose of this retrospective study was to further examine the risk factors for developing severe oral mucositis in patients with oral cancer undergoing radiotherapy as a compliment to a previous study performed by our group. Materials and methods: A total of 181 patients with oral cancer undergoing radiotherapy were enrolled in the study. The association between a number of potential risk factors and grade 3 oral mucositis were analyzed using the cox proportional hazard model and a logistic regression analysis. Results: Grade 3 oral mucositis occurred in 56 patients. The cox proportional hazard model analysis revealed that those with lower hemoglobin levels, concurrent cisplatin and cetuximab administration, and a larger number of teeth showed a significantly higher incidence of severe oral mucositis. Logistic regression analysis revealed that patients who had lower hemoglobin levels, received concurrent cisplatin or cetuximab treatment, and were not administered pilocarpine showed a significantly higher incidence of severe oral mucositis. The presence of teeth may stimulate the oral mucosa and become a risk factor for mucositis, and the administration of pilocarpine might reduce the risk. Conclusion: This study describes the risk factors of severe radiation-induced oral mucositis in oral cancer patients and shows the possibility of risk reduction by pilocarpine. This information could help patients avoid painful mucositis.

【 授权许可】

Unknown